Disease encyclopedia/Blood, immune & lymph
    3-D atlas
    Blood, immune & lymphCancerICD-10 C81–C85

    Lymphoma

    Also called: Hodgkin lymphoma, Non-Hodgkin lymphoma

    Cancer of lymphocytes, typically causing painless swelling of lymph nodes in the neck, armpit or groin.

    Condition-specific references are below. Individual claims and this page have not been clinically reviewed. Read about this content.

    Affected: Lymph nodes, Spleen

    Causes

    • Mutations in lymphocytes; some linked to viruses (EBV, HIV)

    Risk factors

    • Weakened immunity
    • Autoimmune disease
    • EBV
    • Family history

    Symptoms

    • Painless swollen lymph nodes
    • Fever, drenching night sweats, weight loss ('B symptoms')
    • Itching
    • Fatigue

    Diagnosis — tests and examinations

    • Lymph node biopsy
    • PET-CT staging
    • Blood tests

    Treatment

    Medicines and medical treatment

    • Chemotherapy (ABVD for Hodgkin, R-CHOP for DLBCL)
    • Rituximab and other antibodies
    • CAR-T and bispecific antibodies for relapse

    Operations and procedures

    • Radiotherapy
    • Stem cell transplant

    Self-care, home remedies and lifestyle

    • Infection precautions

    Possible complications

    • Infections
    • Late treatment effects

    Prevention

    • None specific

    Outlook

    Hodgkin lymphoma is cured in over 85%; many non-Hodgkin types are curable or controllable.

    When to see a doctor

    See a doctor for lymph nodes swollen more than 3 weeks or with night sweats and weight loss.

    Sources and further reading

    These sources cover this condition. They have not been checked against every statement on this page.

    • Lymphoma — MedlinePlus (U.S. National Library of Medicine)

    Related conditions

    Sickle cell diseaseThalassaemiaIron-deficiency anaemiaLeukaemiaHaemophiliaSystemic lupus erythematosus

    Educational overview, not medical advice. Treatment varies by person and location. Consult a qualified health professional for diagnosis or care. Read our content and model notes and privacy information.

    Affected: Lymph nodes, Spleen

    See it in 3-D

    Cervical lymph nodes (left)Axillary lymph nodes (left)Spleen

    Anatomy

    • Cervical lymph nodes
    • Axillary lymph nodes
    • Spleen

    On this page

    • Causes
    • Risk factors
    • Symptoms
    • Diagnosis — tests and examinations
    • Treatment
    • Complications
    • Prevention
    • Outlook
    • When to see a doctor
    • Sources