Disease encyclopedia/Hormones & metabolism
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    Hormones & metabolismHormonal/metabolicICD-10 E28.2

    Polycystic ovary syndrome

    Also called: PCOS

    A common hormonal condition with irregular or absent ovulation, excess male hormones and often multiple small follicles on the ovaries. It is linked to insulin resistance.

    Condition-specific references are below. Individual claims and this page have not been clinically reviewed. Read about this content.

    About 1 in 10 women of reproductive age.

    Affected: Ovaries, Pancreas (insulin)

    Causes

    • Genetic predisposition, insulin resistance and hormonal imbalance

    Risk factors

    • Family history
    • Obesity

    Symptoms

    • Irregular or absent periods
    • Excess hair growth
    • Acne
    • Hair thinning
    • Difficulty conceiving
    • Weight gain

    Diagnosis — tests and examinations

    • Rotterdam criteria: two of irregular ovulation, high androgens, polycystic ovaries on ultrasound
    • Blood tests (testosterone, AMH, glucose, lipids)

    Treatment

    Medicines and medical treatment

    • Combined oral contraceptive for cycles and symptoms
    • Metformin for insulin resistance
    • Letrozole to induce ovulation
    • Anti-androgens (spironolactone) for hair growth

    Operations and procedures

    • IVF if needed
    • Ovarian drilling rarely

    Self-care, home remedies and lifestyle

    • Weight loss of 5–10% often restores ovulation
    • Regular exercise
    • Healthy diet

    Possible complications

    • Infertility
    • Type 2 diabetes
    • Endometrial hyperplasia
    • Cardiovascular risk
    • Depression

    Prevention

    • Healthy weight reduces severity

    Outlook

    Well managed with lifestyle and medication; most can conceive with treatment.

    When to see a doctor

    See a doctor for irregular periods, excess hair growth or difficulty conceiving.

    Sources and further reading

    These sources cover this condition. They have not been checked against every statement on this page.

    • Polycystic ovary syndrome — MedlinePlus (U.S. National Library of Medicine)

    Related conditions

    Type 2 diabetesType 1 diabetesHypothyroidism (underactive thyroid)Hyperthyroidism (overactive thyroid)Thyroid cancerCushing's syndrome

    Educational overview, not medical advice. Treatment varies by person and location. Consult a qualified health professional for diagnosis or care. Read our content and model notes and privacy information.

    Affected: Ovaries, Pancreas (insulin)

    See it in 3-D

    Ovary (left)

    Anatomy

    • Ovary

    On this page

    • Causes
    • Risk factors
    • Symptoms
    • Diagnosis — tests and examinations
    • Treatment
    • Complications
    • Prevention
    • Outlook
    • When to see a doctor
    • Sources